E4630
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E4630
Sigma
Ethambutol dihydrochloride
| Synonym: | Emb, 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride |
| CAS Number: | 1070-11-7 |
| Linear Formula: | C10H24N2O2 · 2HCl |
| Molecular Weight: | 277.23 |
| EC Number: | 213-970-7 |
| MDL number: | MFCD00216025 |
| PubChem Substance ID: | 24894566 |
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Description
| Application | Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. |
| Biochem/physiol Actions | Ethambutol specifically inhibits arabinosyltransferases in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria.1,2 |
Safety
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | EL3854000 |
References
| Cited Reference | 1. Belanger, A.E., et al., The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc. Natl. Acad. Sci. U. S. A. 93, 11919-24, (1996) |
| 2. Khoo, K.H., et al., Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol. J. Biol. Chem. 271, 28682-90, (1996) | |
| Merck | Merck 13,3755 |
